Scott, my 2 cents on this relates to how long at what temperature:
This is very interesting to me in terms of time and temperature effects on hop contribution to bitterness. Alpha Acids from hops isomerize during the boil to other compounds (bitter, in a good way) and then those compounds can change into not-so-good flavored compounds (bitter, in a bad way).
At the pH of the sweet liquor from the mash, the not-very-water-soluble humulones melt above 62 ºC and begin to isomerize (according to other sources) at temperatures above 80 ºC. The rate of change into good bitterness is tied to the temperature - higher T, faster rate. But don’t go for a pressure cooker, because the rate of degradation to bad flavors speeds up at higher T, too. The paper cited below looked at the rate of the isomerization reaction above 90 ºC. The rate below 90 ºC is so slow that it is boring.
What does any of this have to do with hopstand or whirlpool? Time & Temperature for recently added hops can impact the bitterness of the beer if only a little bit. Say you added hops for flavor at 30 min. If that (arbitrary) 30 minutes of boil time even starts to contribute measurable bitterness, then a 30 min hopstand at >90 ºC after flameout means that those hops are more bettering, less flavoring than you thought. If the wort temperature goes below 90 ºC, the rate is very slow, and if it goes below 80ºC, consider it negligible. What counts most is the total time at T >90 ºC and maybe >80 ºC, to a lesser degree. The term "hopstand" needs time and temperature attached to it. Sort of a recipe integrity thingy.
I am trying to keep track of my late hop additions relative to the future timepoint where the temperature goes below 90 ºC, then 80 ºC. There’s a lot of variables with my crude set-up, not to mention my brewing different recipes all the time.
For the more technical, see the abstract at
http://pubs.acs.org/doi/abs/10.1021/jf0481296 (paywall to the full article) The last sentence there concurs with the idea that hops should not be boiled for longer than 60 min. FWH is a different discussion.
